Comparative computational study to augment UbiA prenyltransferases inherent in purple photosynthetic bacteria cultured from mangrove microbial mats in Qatar for coenzyme Q₁₀ biosynthesis.

ABSTRACT: Coenzyme Q₁₀ (CoQ₁₀) is a powerful antioxidant with a myriad of applications in healthcare and cosmetic industries. The most effective route of CoQ₁₀ production is microbial biosynthesis. In this study, four CoQ₁₀ biosynthesizing purple photosynthetic bacteria: Rhodobacter blasticus, Rhodovulum adriaticum, Afifella pfennigii and Rhodovulum marinum, were identified using 16S rRNA sequencing of enriched microbial mat samples obtained from Purple Island mangroves (Qatar). The membrane bound enzyme 4-hydroxybenzoate octaprenyltransferase (UbiA) is pivotal for bacterial biosynthesis of CoQ₁₀. The identified bacteria could be inducted as efficient industrial bio-synthesizers of CoQ₁₀ by engineering their UbiA enzymes

SUBMITTER: George DM 

PROVIDER: S-EPMC9672418 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature