Improved MAIT cell functions following fecal microbiota transplantation for metastatic renal cell carcinoma.

ABSTRACT: Strategies to modify the gut microbiome in cancer patients using fecal microbiota transplantation (FMT) have gained momentum as a therapeutic intervention. However, how FMT impacts innate-like, antimicrobial T lymphocytes is unclear. In this study, we assessed peripheral blood (PB) mucosa-associated invariant T (MAIT) cell frequencies and functions in patients with metastatic renal cell carcinoma (mRCC) before and seven days after they received FMT as part of a clinical trial. We found comparable MAIT cell frequencies in healthy controls and mRCC patients. In contrast, γδ T cells exhibited a numerical decline in mRCC, which was partially reversed by FMT. We also found a significant increase in the PB CD4⁺ MAIT cell compartment of mRCC patients with or without FMT. Paired sample

SUBMITTER: Ninkov M 

PROVIDER: S-EPMC9672546 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature