Transmission of multidrug-resistant tuberculosis in Beijing, China: An epidemiological and genomic analysis.

ABSTRACT:

Background

Understanding multidrug-resistant tuberculosis (MDR-TB) transmission patterns is crucial for controlling the disease. We aimed to identify high-risk populations and geographic settings of MDR-TB transmission.

Methods

We conducted a population-based retrospective study of MDR-TB patients in Beijing from 2018 to 2020, and assessed MDR-TB recent transmission using whole-genome sequencing of isolates. Geospatial analysis was conducted with kernel density estimation. We combined TransPhylo software with epidemiological investigation data to construct transmission networks. Logistic regression analysis was utilized to identify risk factors for recent transmission.

Results

We included 241 MDR-TB patients, of which 146 (60.58%) were available for genomic analysis.

SUBMITTER: Yin J 

PROVIDER: S-EPMC9672842 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature