Histamine Signaling Is Essential for Tissue Macrophage Differentiation and Suppression of Bacterial Overgrowth in the Stomach.

ABSTRACT:

Background & aims

Histamine in the stomach traditionally is considered to regulate acid secretion but also has been reported to participate in macrophage differentiation, which plays an important role in tissue homeostasis. Therefore, this study aimed to uncover the precise role of histamine in mediating macrophage differentiation and in maintaining stomach homeostasis.

Methods

Here, we expand on this role using histidine decarboxylase knockout (Hdc^-/-) mice with hypertrophic gastropathy. In-depth in vivo studies were performed in Hdc^-/- mice, germ-free Hdc^-/- mice, and bone-marrow-transplanted Hdc^-/- mice. The stomach macrophage populations and function were characterized by flow cytometry. To identify stomach macrophages and find

SUBMITTER: Kim KH 

PROVIDER: S-EPMC9672892 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature