Retinal Vascular Plexuses Are Unequally Affected in Canine Inherited Retinal Degenerations.

ABSTRACT:

Purpose

To characterize the progression of vascular changes that occur in each retinal plexus, in three canine models of inherited retinal degeneration.

Methods

In this retrospective cohort study, we examined the retinal imaging records of 44 dogs from a research colony that had undergone optical coherence tomography angiography (OCTA) imaging. Animals enrolled included crd2/NPHP5 and xlpra2/RPGR mutant dogs imaged at different stages of photoreceptor loss, as well as RHOT4R/+ dogs after acute light-induced rod degeneration. Also included were normal controls imaged at similar ages. OCT angiograms of the superficial vascular plexus combined with the intermediate capillary plexus (SVP + ICP), and the deep capillary plexus (DCP) were analyzed using the AngioTool software to ca

SUBMITTER: Ripolles-Garcia A 

PROVIDER: S-EPMC9672900 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature