Persistence of hippocampal and striatal multivoxel patterns during awake rest after motor sequence learning.

ABSTRACT: Memory consolidation, the process by which newly encoded and fragile memories become more robust, is thought to be supported by the reactivation of brain regions - including the hippocampus - during post-learning rest. While hippocampal reactivations have been demonstrated in humans in the declarative memory domain, it remains unknown whether such a process takes place after motor learning. Using multivariate analyses of task-related and resting state fMRI data, here we show that patterns of brain activity within both the hippocampus and striatum elicited during motor learning persist into post-learning rest, indicative of the reactivation of learning-related neural activity patterns. Moreover, results indicate that hippocampal reactivation reflects the spatial representation of the learne

SUBMITTER: King BR 

PROVIDER: S-EPMC9672934 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature