Lactobacillus reuteri normalizes altered fear memory in male Cntnap4 knockout mice.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a common neurodevelopmental disease, characterized by deficits in social communication, restricted and repetitive behaviours, and impaired fear memory processing. Severe gastrointestinal dysfunction and altered gut microbiome have been reported in ASD patients and animal models. Contactin associated protein-like 4 (CNTNAP4) has been suggested to be a novel risk gene, though its role in ASD remains unelucidated.

Methods

Cntnap4^-/- mice were generated to explore its role in ASD-related behavioural abnormalities. Electrophysiological recording was employed to examine GABAergic transmission in the basolateral amygdala (BLA) and prefrontal cortex. RNA-sequencing was performed to assess underlying mechanisms. 16S rDNA analysi

SUBMITTER: Zhang W 

PROVIDER: S-EPMC9672961 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature