A peripheral immune signature of responsiveness to PD-1 blockade in patients with classical Hodgkin lymphoma.

ABSTRACT: PD-1 blockade is highly effective in classical Hodgkin lymphomas (cHLs), which exhibit frequent copy-number gains of CD274 (PD-L1) and PDC1LG2 (PD-L2) on chromosome 9p24.1. However, in this largely MHC-class-I-negative tumor, the mechanism of action of anti-PD-1 therapy remains undefined. We utilized the complementary approaches of T cell receptor (TCR) sequencing and cytometry by time-of-flight analysis to obtain a peripheral immune signature of responsiveness to PD-1 blockade in 56 patients treated in the CheckMate 205 phase II clinical trial (NCT02181738). Anti-PD-1 therapy was most effective in patients with a diverse baseline TCR repertoire and an associated expansion of singleton clones during treatment. CD4⁺, but not CD8⁺, TCR diversity significantly increased

SUBMITTER: Cader FZ 

PROVIDER: S-EPMC9673009 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature