Associations of Alzheimer Disease-Protective APOE Variants With Age-Related Macular Degeneration.

ABSTRACT:

Importance

The association of major lipid genes with and their potential as drug targets for age-related macular degeneration (AMD) is unknown. These associations are important to study because AMD is the leading cause of irreversible late-onset blindness in high-income countries.

Objective

To determine whether the full range of structural genetic variation in apolipoprotein E (APOE), a master gene in peripheral and cerebral lipid metabolism, is associated with risk of AMD.

Design, setting, and participants

This cohort study used data from the Copenhagen City Heart Study (CCHS) and the Copenhagen General Population Study (CGPS) cohorts. Participants were followed from study inclusion at the time of blood sampling to occurrence of event, death, emigration, or December

SUBMITTER: Rasmussen KL 

PROVIDER: S-EPMC9673029 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature