Anakinra or high-dose corticosteroids in COVID-19 pneumonia patients who deteriorate on low-dose dexamethasone: an observational study of comparative effectiveness.

ABSTRACT:

Objectives

To assess whether escalating to high-dose corticosteroids or anakinra compared with continuing low-dose corticosteroids reduced mortality in patients with severe COVID-19 whose respiratory function deteriorated while receiving dexamethasone 6 mg daily.

Methods

We conducted a retrospective cohort study between March 1 to December 31, 2020, of hospitalized patients with confirmed COVID-19 pneumonia. In-hospital death was analyzed using logistic regression with inverse probability of treatment weighting of receiving anakinra, high-dose corticosteroid (dexamethasone >10 mg daily), or remaining on low-dose corticosteroids on the day of first respiratory deterioration.

Results

We analyzed 6671 patients whose respiratory status deteriorated while receiving dexamet

SUBMITTER: Langer-Gould A 

PROVIDER: S-EPMC9673073 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature