Differential endothelial hydrogen peroxide signaling via Nox isoforms: Critical roles for Rac1 and modulation by statins.

ABSTRACT: Statins have manifold protective effects on the cardiovascular system. In addition to lowering LDL cholesterol levels, statins also have antioxidant effects on cardiovascular tissues involving intracellular redox pathways that are incompletely understood. Inhibition of HMG-CoA reductase by statins not only modulates cholesterol synthesis, but also blocks the synthesis of lipids necessary for the post-translational modification of signaling proteins, including the GTPase Rac1. Here we studied the mechanisms whereby Rac1 and statins modulate the intracellular oxidant hydrogen peroxide (H₂O₂) via NADPH oxidase (Nox) isoforms. In live-cell imaging experiments using the H₂O₂ biosensor HyPer7, we observed robust H₂O₂ generation in

SUBMITTER: Waldeck-Weiermair M 

PROVIDER: S-EPMC9673117 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature