Multiomic analysis reveals microbiome-related relationships between cocaine use and metabolites.

ABSTRACT:

Objective

Over 19 million individuals globally have a cocaine use disorder, a significant public health crisis. Cocaine has also been associated with a pro-inflammatory state and recently with imbalances in the intestinal microbiota as compared to nonuse. The objective of this pilot study was to characterize the gut microbiota and plasma metabolites in people with HIV (PWH) who use cocaine compared with those who do not.

Design

Cross-sectional study.

Methods

A pilot study in PWH was conducted on 25 cocaine users and 25 cocaine nonusers from the Miami Adult Studies on HIV cohort. Stool samples and blood plasma were collected. Bacterial composition was characterized using 16S rRNA sequencing. Metabolomics in plasma were determined using gas and liquid chromatography/mas

SUBMITTER: Martinez SS 

PROVIDER: S-EPMC9673179 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature