Placebo Response in Trials of Negative Symptoms in Schizophrenia: A Critical Reassessment of the Evidence.

ABSTRACT:

Background

Summarizing evidence from clinical trials of patients with schizophrenia with predominant or prominent negative symptoms (NS), a prior meta-analysis reported a large placebo effect in negative symptoms (Cohen's d = 2.909). Assuming that such an effect was clinically not plausible, we performed a critical re-assessment and an update of the previous results with newly available data from add-on and monotherapy studies.

Study design

Random-effect meta/regression analysis of trials that focused on predominant or prominent NS; and adopted a double-blind, randomized, placebo-controlled design. The final pooled meta-analytic database, based on the available add-on and monotherapy studies combined, included 24 publications containing data on a total of 25 studies (21 add-

SUBMITTER: Czobor P 

PROVIDER: S-EPMC9673255 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature