Virome and nrEVEome diversity of Aedes albopictus mosquitoes from La Reunion Island and China.

ABSTRACT:

Background

Aedes albopictus is a public health threat for its worldwide spread and ability to transmit arboviruses. Understanding mechanisms of mosquito immunity can provide new tools to control arbovirus spread. The genomes of Aedes mosquitoes contain hundreds of nonretroviral endogenous viral elements (nrEVEs), which are enriched in piRNA clusters and produce piRNAs, with the potential to target cognate viruses. Recently, one nrEVE was shown to limit cognate viral infection through nrEVE-derived piRNAs. These findings suggest that nrEVEs constitute an archive of past viral infection and that the landscape of viral integrations may be variable across populations depending on their viral exposure.

Methods

We used bioinformatics and molecular approaches to identify known and

SUBMITTER: Palatini U 

PROVIDER: S-EPMC9673329 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature