The prognostic role of tumor mutation burden on survival of breast cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

As a potential genetic biomarker, tumor mutation burden (TMB) has made progress in numerous tumors. There are limited data regarding TMB and its prognostic role is controversial in breast cancer. This systematic review and meta-analysis were conducted to assess the prognostic value of TMB on survival of breast cancer.

Methods

The databases PubMed, Embase, Web of Science, and Cochrane Library were searched for articles published through May 31, 2022. Moreover, effective data were extracted from included studies and calculated pooled effects of hazard ratio (HR) for overall survival (OS) and progression-free survival (PFS) by STATA 16.0. Heterogeneity was conducted by the I² statistic and p-value. Using publication bias evaluation, sensitivity analysis, a

SUBMITTER: Ke L 

PROVIDER: S-EPMC9673350 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature