Prevalence of familial autoimmune diseases in juvenile idiopathic arthritis: results from the international Pharmachild registry.

ABSTRACT:

Background

Little is known about the disposition to autoimmune diseases (ADs) among children diagnosed with JIA. In this study, we provide a comprehensive overview of the prevalence of and factors associated with ADs in parents of children with juvenile idiopathic arthritis (JIA).

Methods

Prevalence rates of ADs and 95% Poisson confidence intervals were calculated for parents of JIA patients from the international Pharmachild registry and compared with general population prevalence rates as reported in the literature. Demographic, clinical and laboratory features were compared between JIA patients with and without a family history of AD using χ² and Mann-Whitney U tests.

Results

Eight thousand six hundred seventy three patients were included and the most co

SUBMITTER: van Straalen JW 

PROVIDER: S-EPMC9673358 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature