Comparison of analysis methods and design choices for treatment-by-period interaction in unidirectional switch designs: a simulation study.

ABSTRACT:

Background

Due to identifiability problems, statistical inference about treatment-by-period interactions has not been discussed for stepped wedge designs in the literature thus far. Unidirectional switch designs (USDs) generalize the stepped wedge designs and allow for estimation and testing of treatment-by-period interaction in its many flexible design forms.

Methods

Under different forms of the USDs, we simulated binary data at both aggregated and individual levels and studied the performances of the generalized linear mixed model (GLMM) and the marginal model with generalized estimation equations (GEE) for estimating and testing treatment-by-period interactions.

Results

The parallel group design had the highest power for detecting the treatment-by-period interactio

SUBMITTER: Zhan Z 

PROVIDER: S-EPMC9673415 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature