Imaging features associated with H3 K27-altered and H3 G34-mutant gliomas: a narrative systematic review.

ABSTRACT:

Background

Advances in molecular diagnostics accomplished the discovery of two malignant glioma entities harboring alterations in the H3 histone: diffuse midline glioma, H3 K27-altered and diffuse hemispheric glioma, H3 G34-mutant. Radiogenomics research, which aims to correlate tumor imaging features with genotypes, has not comprehensively examined histone-altered gliomas (HAG). The aim of this research was to synthesize the current published data on imaging features associated with HAG.

Methods

A systematic search was performed in March 2022 using PubMed and the Cochrane Library, identifying studies on the imaging features associated with H3 K27-altered and/or H3 G34-mutant gliomas.

Results

Forty-seven studies fulfilled the inclusion criteria, the majority on H3 K27

SUBMITTER: Lasocki A 

PROVIDER: S-EPMC9673447 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature