A quantitative characterization of the spatial distribution of brain metastases from breast cancer and respective molecular subtypes.

ABSTRACT:

Purpose

Brain metastases (BM) remain a significant cause of morbidity and mortality in breast cancer (BC) patients. Specific factors promoting the process of BM and predilection for selected neuro-anatomical regions remain unknown, yet may have major implications for prevention or treatment. Anatomical spatial distributions of BM from BC suggest a predominance of metastases in the hindbrain and cerebellum. Systematic approaches to quantifying BM location or location-based analyses based on molecular subtypes, however, remain largely unavailable.

Methods

We analyzed stereotactic Cartesian coordinates derived from 134 patients undergoing gamma- knife radiosurgery (GKRS) for treatment of 407 breast cancer BMs to quantitatively study BM spatial distribution along principal compo

SUBMITTER: Mahmoodifar S 

PROVIDER: S-EPMC9673482 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature