Temporal Trends in Lipoprotein(a) Concentrations: The Atherosclerosis Risk in Communities Study.

ABSTRACT: Background Plasma lipoprotein(a) (Lp[a]) concentrations are primarily determined by genetic factors and are believed to remain stable throughout life. However, data are scarce on longitudinal trends in Lp(a) concentrations over time. Therefore, it is unclear whether measurement of Lp(a) once in a person's life is sufficient for cardiovascular risk assessment in all adults. Methods and Results Lp(a) concentrations, specifically apolipoprotein(a) concentrations, were measured at visits 4 and 5, ≈15 years apart, in 4734 adult participants of the ARIC (Atherosclerosis Risk in Communities) study (mean age at visits 4 and 5, 60.7±5.1 and 75.5±5.2 years, respectively). Participants were categorized by baseline (visit 4) Lp(a) concentrations as normal (<30 mg/dL), borderline-high (30-49 mg/dL), or

SUBMITTER: Deshotels MR 

PROVIDER: S-EPMC9673625 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature