Associations of Childhood Maltreatment and Genetic Risks With Incident Heart Failure in Later Life.

ABSTRACT: Background We aimed to determine the associations of childhood maltreatment with incident heart failure in later life and explore the potentially modifying effects of genetic risk for heart failure on the associations. Methods and Results This cohort study included adults free of heart failure at baseline enrolled between 2006 and 2010 in the UK Biobank. Childhood maltreatment was retrospectively assessed with the online Childhood Trauma Screener in 2016. Five types of childhood maltreatment (range, 0-5), including physical abuse, physical neglect, emotional abuse, emotional neglect, and sexual abuse, were combined into a total score. A weighted polygenic risk score for heart failure was constructed. Incident all-cause heart failure was prospectively ascertained via hospital inpatient and

SUBMITTER: Liang YY 

PROVIDER: S-EPMC9673679 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature