Large-Scale Targeted Sequencing Study of Ischemic Stroke in the Han Chinese Population.

ABSTRACT: Background Ischemic stroke is likely caused by interactions of multiple genes and environmental determinants. However, large-scale sequencing studies to discern functional genetic variants and their interactions with clinical and lifestyle risk factors on ischemic stroke are limited. Methods and Results We sequenced functional regions of 740 previously identified genes associated with atherosclerotic disease among 999 ischemic stroke cases and 1001 controls of Chinese ancestry. Multiple logistic regression models were used to examine the associations between variants and ischemic stroke and test interactions between variants and clinical and lifestyle risk factors. Functional variants achieving suggestive significance were replicated in an independent sample of 4724 ischemic stroke cases a

SUBMITTER: Shi M 

PROVIDER: S-EPMC9673712 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature