Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure.

ABSTRACT: Background Poor cardiovascular health during pregnancy has been associated with adverse neurocognitive outcomes in the offspring. We examined the associations of maternal cardiovascular health factors with brain structure in 10-year-old children. Methods and Results We included 2797 mother-offspring pairs from the Generation R Study. Maternal body mass index, gestational weight gain, blood pressure, insulin, glucose, and lipid blood concentrations were obtained in early pregnancy. Childhood structural brain measures, including global metrics of brain tissue volumes and white matter microstructure, were quantified by magnetic resonance imaging at 10 years. As compared with offspring of mothers with normal weight, those of mothers with underweight had smaller total brain volume (difference,

SUBMITTER: Silva CCV 

PROVIDER: S-EPMC9673736 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature