Lipidome- and Genome-Wide Study to Understand Sex Differences in Circulatory Lipids.

ABSTRACT: Background Despite well-recognized differences in the atherosclerotic cardiovascular disease risk between men and women, sex differences in risk factors and sex-specific mechanisms in the pathophysiology of atherosclerotic cardiovascular disease remain poorly understood. Lipid metabolism plays a central role in the development of atherosclerotic cardiovascular disease. Understanding sex differences in lipids and their genetic determinants could provide mechanistic insights into sex differences in atherosclerotic cardiovascular disease and aid in precise risk assessment. Herein, we examined sex differences in plasma lipidome and heterogeneity in genetic influences on lipidome in men and women through sex-stratified genome-wide association analyses. Methods and Results We used data consistin

SUBMITTER: Tabassum R 

PROVIDER: S-EPMC9673737 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature