Clinical assessment of endothelial function in convalescent COVID-19 patients: a meta-analysis with meta-regressions.

ABSTRACT:

Background

Endothelial dysfunction has been proposed to play a key role in the pathogenesis of coronavirus disease 2019 (COVID-19) and its post-acute sequelae. Flow-mediated dilation (FMD) is recognized as an accurate clinical method to assess endothelial function. Thus, we performed a meta-analysis of the studies evaluating FMD in convalescent COVID-19 patients and controls with no history of COVID-19.

Methods

A systematic literature search was conducted in the main scientific databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Using the random effects method, differences between cases and controls were expressed as mean difference (MD) with 95% confidence intervals (95% CI). The protocol was registered on PROSP

SUBMITTER: Ambrosino P 

PROVIDER: S-EPMC9673781 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature