Cost-effectiveness of population-wide genomic screening for Lynch syndrome in the United States.

ABSTRACT:

Purpose

Genomic screening for Lynch syndrome (LS) could prevent colorectal cancer (CRC) by identifying high-risk patients and instituting intensive CRC screening. We estimated the cost-effectiveness of a population-wide LS genomic screening vs family history-based screening alone in an unselected US population.

Methods

We developed a decision-analytic Markov model including health states for precancer, stage-specific CRC, and death and assumed an inexpensive test cost of $200. We conducted sensitivity and threshold analyses to evaluate model uncertainty.

Results

Screening unselected 30-year-olds for LS variants resulted in 48 (95% credible range [CR] = 35-63) fewer overall CRC cases per 100,000 screened individuals, leading to 187 quality-adjusted life-years (QALYs; 9

SUBMITTER: Guzauskas GF 

PROVIDER: S-EPMC9673900 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature