Retaining Participants in Longitudinal Studies of Alzheimer's Disease.

ABSTRACT:

Background

Retention of study participants is essential to advancing Alzheimer's disease (AD) research and developing therapeutic interventions. However, recent multi-year AD studies have lost 10% to 54% of participants.

Objective

We surveyed a random sample of 443 participants (Clinical Dementia Rating [CDR]≤1) at four Alzheimer Disease Research Centers to elucidate perceived facilitators and barriers to continued participation in longitudinal AD research.

Methods

Reasons for participation were characterized with factor analysis. Effects of perceived fulfillment of one's own goals and complaints on attendance and likelihood of dropout were estimated with logistic regression models. Open-ended responses suggesting study improvements were analyzed with a Latent Dirichl

SUBMITTER: Gabel M 

PROVIDER: S-EPMC9673904 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature