Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model.

ABSTRACT: A relatively low clearance is one of the prominent favorable features of immunoglobulin G1-based therapeutic monoclonal antibodies (mAbs). Various studies have observed differential clearance of mAb glycoforms, including oligomannose glycoforms, which are considered a critical quality attribute because they show higher clearance than complex type glycoforms. Glycoform clearance, however, has not previously been studied after subcutaneous injection or in a porcine model system. Here, we performed glycoform-resolved pharmacokinetic (PK) analysis of two mAbs in Göttingen minipigs. We found glycoform effects on clearance to be largely the same for subcutaneous and intravenous injection and in line with observations in other species. Oligomannose glycoforms were cleared up to 25% faster and mon

SUBMITTER: Falck D 

PROVIDER: S-EPMC9673920 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature