On the predictibility of A-minor motifs from their local contexts.

ABSTRACT: This study investigates the importance of the structural context in the formation of a type I/II A-minor motif. This very frequent structural motif has been shown to be important in the spatial folding of RNA molecules. We developed an automated method to classify A-minor motif occurrences according to their 3D context similarities, and we used a graph approach to represent both the structural A-minor motif occurrences and their classes at different scales. This approach leads us to uncover new subclasses of A-minor motif occurrences according to their local 3D similarities. The majority of classes are composed of homologous occurrences, but some of them are composed of non-homologous occurrences. The different classifications we obtain allow us to better understand the importance of the c

SUBMITTER: Gianfrotta C 

PROVIDER: S-EPMC9673937 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature