Gene co-expression network analysis of the human gut commensal bacterium Faecalibacterium prausnitzii in R-Shiny.

ABSTRACT: Faecalibacterium prausnitzii is abundant in the healthy human intestinal microbiota, and the absence or scarcity of this bacterium has been linked with inflammatory diseases and metabolic disorders. F. prausnitzii thus shows promise as a next-generation probiotic for use in restoring the balance of the gut microbial flora and, due to its strong anti-inflammatory properties, for the treatment of certain pathological conditions. However, very little information is available about gene function and regulation in this species. Here, we utilized a systems biology approach-weighted gene co-expression network analysis (WGCNA)-to analyze gene expression in three publicly available RNAseq datasets from F. prausnitzii strain A2-165, all obtained in different laboratory conditions. The co-expression

SUBMITTER: Auger S 

PROVIDER: S-EPMC9674144 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature