DMFpred: Predicting protein disorder molecular functions based on protein cubic language model.

ABSTRACT: Intrinsically disordered proteins and regions (IDP/IDRs) are widespread in living organisms and perform various essential molecular functions. These functions are summarized as six general categories, including entropic chain, assembler, scavenger, effector, display site, and chaperone. The alteration of IDP functions is responsible for many human diseases. Therefore, identifying the function of disordered proteins is helpful for the studies of drug target discovery and rational drug design. Experimental identification of the molecular functions of IDP in the wet lab is an expensive and laborious procedure that is not applicable on a large scale. Some computational methods have been proposed and mainly focus on predicting the entropic chain function of IDRs, while the computational predict

SUBMITTER: Pang Y 

PROVIDER: S-EPMC9674156 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature