A neuropeptide signal confers ethanol state dependency during olfactory learning in Caenorhabditis elegans.

ABSTRACT: Alcohol intoxication can impact learning and this may contribute to the development of problematic alcohol use. In alcohol (ethanol)-induced state-dependent learning (SDL), information learned while an animal is intoxicated is recalled more effectively when the subject is tested while similarly intoxicated than if tested while not intoxicated. When Caenorhabditis elegans undergoes olfactory learning (OL) while intoxicated, the learning becomes state dependent such that recall of OL is only apparent if the animals are tested while intoxicated. We found that two genes known to be required for signal integration, the secreted peptide HEN-1 and its receptor tyrosine kinase, SCD-2, are required for SDL. Expression of hen-1 in the ASER neuron and scd-2 in the AIA neurons was

SUBMITTER: Lindsay JH 

PROVIDER: S-EPMC9674237 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature