Dataset Information

A retrospective study of COVID during pregnancy and the outcome of vaginal delivery.

ABSTRACT:

Introduction

SARS-CoV, MERS-CoV, and SARS-CoV-2, later named coronavirus disease 2019 (COVID-19), are three highly pathogenic and lethal human coronaviruses that have arisen in the last two decades. Pregnant women have a higher risk due to a special state of immunosuppression. However, there is no proof that pregnant women and their babies are more vulnerable to infection, as data is limited.The primary goal of this retrospective study is to examine the effects of early COVID-19 diagnosis and to address the best method of delivery based on medical records of neonatal and maternal outcomes observed at Nepal's Paropakar Maternity Hospital. This retrospective research will determine whether vaginal delivery is healthy compared to cesarean delivery and whether the outcome of a COVID-19 pregnancy in both mother and the baby is independent of the disease's status of the mother.

Methods

Study design: The proposed study is a retrospective cross-sectional study.

Patients population

104 cases of COVID positive pregnancy with vaginal delivery or caesarean section.

Results

The neonatal outcomes of COVID pregnancy revealed at least 51% baby born with Low APGAR score, 18% born prematurely, 19% with low birth weight, 7% requiring NICU admission, 3% Neonatal asphyxia, and 2% Neonatal death. Furthermore, when normal vaginal delivery and Cesarean section were compared there was no significant between the differences found in the outcomes.

Conclusion

The COVID positive status had no association with the perinatal outcomes. Moreover, COVID status rarely affected the course of pregnancy.

Guideline

STROCSS 2021.

SUBMITTER: Sunuwar N

PROVIDER: S-EPMC9674396 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Publications

A retrospective study of COVID during pregnancy and the outcome of vaginal delivery.

Sunuwar Neela N Jaishi Prakash Poudel PP Twayana Anu Radha AR Neupane Prabhat Kiran PK Neupane Sandhya Kiran SK

Annals of medicine and surgery (2012) 20221119

<h4>Introduction</h4>SARS-CoV, MERS-CoV, and SARS-CoV-2, later named coronavirus disease 2019 (COVID-19), are three highly pathogenic and lethal human coronaviruses that have arisen in the last two decades. Pregnant women have a higher risk due to a special state of immunosuppression. However, there is no proof that pregnant women and their babies are more vulnerable to infection, as data is limited.The primary goal of this retrospective study is to examine the effects of early COVID-19 diagnosi ...[more]

PMID: 36438876

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Project description:Reproductive performance is paramount to the success of livestock production enterprises focused on lamb meat production. Reproductive success is influenced by various factors, possibly including the reproductive tract microbial communities present at the time of copulation and throughout pregnancy. There are few publications that identify the vaginal microbial communities of livestock, and even fewer exist for sheep. To compare ewe vaginal microbial communities, vaginal swabs were taken from 67 Hampshire and Hampshire X Suffolk crossbred ewes from the Iowa State University sheep farm at a pre-breeding time point (S1) and after pregnancy testing (S2). Animals that were determined pregnant were sampled again within a few days of expected parturition (S3). DNA was extracted from these swabs, and 16S rRNA gene Illumina MiSeq amplicon sequencing was conducted to fingerprint the bacterial communities found within this system. Pre-breeding time point samples showed no differences in community structure between animals later found to be pregnant or non-pregnant, but significant changes were detected in species richness (Chao; P < 0.001) and species diversity (Shannon; P < 0.001) at the second sampling time point. A higher microbial diversity within the S2 time point samples may suggest a more stable environment driven by pregnancy, as this increased diversity is maintained in pregnant animals from the S2 to the S3 time point. Additionally, several bacterial phylotypes, such as Mannheimia, Oscillospiraceae-like OTUs and Alistipes, were more abundant at either the S1 or S2 time points in animals that established pregnancy, suggesting a beneficial effect on pregnancy outcome. This study identifies changes within the microbial communities of the ewe vagina before and during gestation and offers inferences on how these changes may impact pregnancy outcome. Information presented herein offers new knowledge about sheep vaginal microbial communities and serves as a starting point to help guide researchers to improve sheep reproductive performance in the future.

Project description:BackgroundShort interpregnancy interval (IPI) following caesarean delivery is associated with uterine rupture in subsequent pregnancies. However, the interval required to minimise this risk is unknown. We investigated how the interval between pregnancies and induction or augmentation of labour affect the likelihood of uterine rupture among parturients with one previous livebirth by caesarean delivery who had a subsequent trial of labour.MethodsIn this population-based cohort study, we used data from U.S National Vital Statistics System from 2011 to 2021. Multiple pregnancies and births of infants with congenital abnormalities were excluded. A linear spline logistic regression with one knot was used to assess the relationship between uterine rupture and interpregnancy interval for spontaneous and for induced/augmented labours. Multivariable logistic regression was performed with multiple imputation and stepwise backward elimination to adjust for maternal demographic and clinical factors including maternal age, height, and BMI and gestational age. The predicted risk of uterine rupture was tabulated for interpregnancy intervals between zero and 21 months. Adverse outcomes were compared between labours with and without uterine rupture.FindingsWe examined 491,998 trials of labour among parturients with one previous livebirth by caesarean delivery and no previous vaginal births. The odds ratio (OR) of uterine rupture per three months interpregnancy interval was 0.91 (95% CI 0.88-0.94) between zero and 21 months after adjusting for confounders, with no further change in risk detected beyond 21 months. The OR was 2.51 (95% CI 2.27-2.78) for induced or augmented labours compared with spontaneous labours. Other factors associated with uterine rupture included older maternal age, shorter maternal height, more advanced gestational age (from 35 to 43 weeks), and heavier birthweight. Predicted rates of uterine rupture ranged from 0.36% at zero to 0.19% at 21 months' interpregnancy interval for spontaneous labours and from 0.91% to 0.47% for induced/augmented labours for parturients with a typical clinical and demographic background. When uterine rupture occurred, the rates of unplanned hysterectomy, intrapartum or neonatal death, and neonatal seizures were 4.0% (95% CI 3.2-5.1%), 3.7% (95% CI 2.7-5.1%), and 2.6% (95% CI 1.8-3.3%) respectively.InterpretationThe risk of uterine rupture progressively decreases as IPI increases until about 21 months and then stabilises. Counselling should advise that for women choosing between a planned TOLAC or a planned caesarean delivery after one previous caesarean delivery and no previous vaginal births waiting until 21 months or longer after a prior low transverse caesarean delivery might minimise the risk of uterine rupture. The absolute risk of certain serious maternal and fetal/neonatal complications such as unplanned hysterectomy and perinatal death is low.FundingNo funding.

Dataset Information

A retrospective study of COVID during pregnancy and the outcome of vaginal delivery.

Introduction

Methods

Patients population

Results

Conclusion

Guideline

Publications

A retrospective study of COVID during pregnancy and the outcome of vaginal delivery.

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