Interleukin-27 Ameliorates Atherosclerosis in ApoE^-/- Mice through Regulatory T Cell Augmentation and Dendritic Cell Tolerance.

ABSTRACT: Atherosclerosis, which is characterized by chronic inflammation in the arterial wall, is driven by immune cells and cytokines. Recent evidence indicated that interleukin (IL)-27 showed pleiotropic properties in immune diseases. However, precise mechanisms of IL-27, especially in atherosclerosis remains unknown. In our research, we examined the influence of the administration of IL-27 and an anti-IL-27p28 antibody (anti-IL-27p28-Ab) on both the initiation and the progression of atherosclerosis. In the groups (both the initiation and the progression) receiving recombinant IL-27 administration, the formation of atherosclerotic plaques was suspended, and the percentage of regulatory T cells (LAP⁺ or Foxp3⁺) in the spleen and peripheral blood was increased. Meanwhile, the

SUBMITTER: Xu W 

PROVIDER: S-EPMC9674420 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature