Loss of myeloid Tsc2 predisposes to angiotensin II-induced aortic aneurysm formation in mice.

ABSTRACT:

Rationale

Genetic studies have proved the involvement of Tuberous sclerosis complex subunit 2 (Tsc2) in aortic aneurysm. However, the exact role of macrophage Tsc2 in the vascular system remains unclear. Here, we examined the potential function of macrophage Tsc2 in the development of aortic remodeling and aortic aneurysms.

Methods and results

Conditional gene knockout strategy combined with histology and whole-transcriptomic analysis showed that Tsc2 deficiency in macrophages aggravated the progression of aortic aneurysms along with an upregulation of proinflammatory cytokines and matrix metallopeptidase-9 in the angiotensin II-induced mouse model. G protein-coupled receptor 68 (Gpr68), a proton-sensing receptor for detecting the extracellular acidic pH, was identified as t

SUBMITTER: Liu X 

PROVIDER: S-EPMC9674579 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature