CaMKII regulates neuromuscular activity and survival of the human blood fluke Schistosoma mansoni.

ABSTRACT: Calcium/calmodulin dependant protein kinase II (CaMKII), an important transducer of Ca²⁺ signals, orchestrates multiple cellular functions in animals. Here we investigated the importance of CaMKII to Schistosoma mansoni, a blood parasite that causes human schistosomiasis. We demonstrate that phosphorylated (activated) CaMKII is present in cercariae, schistosomula and adult worms, and show that striking activation occurs in the nervous tissue of these parasite life-stages; CaMKII was also activated in the tegument and muscles of adult worms and the vitellaria of females. Exposure of worms to the anti-schistosomal drug praziquantel (PZQ) induced significant CaMKII activation and depletion of CaMKII protein/activation in adult worms resulted in hypokinesia, reduced vitality and dea

SUBMITTER: Hirst NL 

PROVIDER: S-EPMC9674609 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature