Decarboxylative oxidation-enabled consecutive C-C bond cleavage.

ABSTRACT: The selective cleavage of C-C bonds is of fundamental interest because it provides an alternative approach to traditional chemical synthesis, which is focused primarily on building up molecular complexity. However, current C-C cleavage methods provide only limited opportunities. For example, selective C(sp³)-C(sp³) bond cleavage generally relies on the use of transition-metal to open strained ring systems or iminyl and alkoxy radicals to induce β-fragmentation. Here we show that by merging photoredox catalysis with copper catalysis, we are able to employ α-trisubstituted carboxylic acids as substrates and achieve consecutive C-C bond cleavage, resulting in the scission of the inert β-CH₂ group. The key transformation relies on the decarboxylative oxidation

SUBMITTER: Li R 

PROVIDER: S-EPMC9674625 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature