Construction and validation of a prognostic model for lung adenocarcinoma based on endoplasmic reticulum stress-related genes.

ABSTRACT: Lung adenocarcinoma (LUAD) is one of the most universal types of cancer all over the world and its morbidity continues to rise year by year. Growing evidence has demonstrated that endoplasmic reticulum stress is highly activated in cancer cells and plays a key role in regulating the fate of cancer cells. However, the role and mechanism of endoplasmic reticulum stress in lung adenocarcinoma genesis and development remains unclear. In this research, we developed a prognostic model to predict the overall survival of patients with LUAD utilizing endoplasmic reticulum stress-related genes and screened out potential small molecular compounds, which could assist the clinician in making accurate decisions and better treat LUAD patients. Firstly, we downloaded 419 endoplasmic reticulum stress-relat

SUBMITTER: Li F 

PROVIDER: S-EPMC9674626 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature