Steep repolarization time gradients in pig hearts cause distinct changes in composite electrocardiographic T-wave parameters.

ABSTRACT:

Background

The T wave of the electrocardiogram (ECG) reflects ventricular repolarization. Repolarization heterogeneity is associated with reentrant arrhythmias. Several T-wave markers (including QT interval) have been associated with ventricular arrhythmias, but studies linking such markers to underlying local repolarization time (RT) inhomogeneities are lacking. We aimed to investigate the relation of several T-wave markers to controlled drug-induced regional RT gradients in intact pig hearts.

Methods

Repolarization time gradients were created by regional infusion of dofetilide and pinacidil in four atrially paced porcine Langendorff-perfused hearts placed inside a torso tank. From the 12-lead ECG on the torso tank, the mean, maximum, and dispersion (max-min) of QT_time

SUBMITTER: van der Waal J 

PROVIDER: S-EPMC9674780 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature