Delivery of the reduced form of vitamin K₂₍₂₀₎ to NIH/3T3 cells partially protects against rotenone induced cell death.

ABSTRACT: Mitochondria generate energy through the action of the electron transport chain (ETC) and ATP synthase. Mitochondrial malfunction can lead to various disorders, including neurodegenerative diseases. Several reports have shown that menaquinone-4 (MK-4, vitamin K₂₍₂₀₎), a safe drug for osteoporosis, may improve mitochondrial function. Here, we hypothesized that the efficient delivery of menahydroquinone-4 (MKH), an active form of MK-4, could exert a supporting effect. We verified the effects of MKH delivery on mitochondrial dysfunction by using MK-4 and MKH ester derivatives in NIH/3T3 mouse fibroblast cells treated with mitochondrial inhibitors. MK-4 and MKH derivatives suppressed cell death, the decline in mitochondrial membrane potential (MMP), excessive reactive oxygen species

SUBMITTER: Toki E 

PROVIDER: S-EPMC9674836 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature