Computational modelling and simulation for immunotoxicity prediction induced by skin sensitisers.

ABSTRACT: In many domains regulating chemicals and chemical products, there is a legal requirement to determine skin sensitivity to allergens. While many in vitro assays to detect contact hypersensitivity have been developed as alternatives to animal testing over the past ten years and significant progress has been made in this area, there is still a need for continued investment in the creation of techniques and strategies that will allow accurate identification of potential contact allergens and their potency in vitro. In silico models are promising tools in this regard. However, none of the state-of-the-art systems seems to function well enough to serve as a stand-alone hazard identification tool, especially in evaluating the possible allergenicity effects in humans. The Universal Immune System S

SUBMITTER: Russo G 

PROVIDER: S-EPMC9674872 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature