Influence of the extracellular domain size on the dynamic behavior of membrane proteins.

ABSTRACT: The dynamic behavior of plasma membrane proteins mediates various cellular processes such as cellular motility, communication, and signaling. It is widely accepted that the dynamics of the membrane proteins is determined either by the interactions of the transmembrane domain with the surrounding lipids or by the interactions of the intracellular domain with cytosolic components such as cortical actin. Although initiation of different cellular signaling events at the plasma membrane has been attributed to the extracellular domain (ECD) properties recently, the impact of ECDs on the dynamic behavior of membrane proteins is rather unexplored. Here, we investigate how ECD properties influence protein dynamics in the lipid bilayer by reconstituting ECDs of different sizes or glycosylation in mo

SUBMITTER: Gurdap CO 

PROVIDER: S-EPMC9674980 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature