Phospholipid headgroups govern area per lipid and emergent elastic properties of bilayers.

ABSTRACT: Phospholipid bilayers are liquid-crystalline materials whose intermolecular interactions at mesoscopic length scales have key roles in the emergence of membrane physical properties. Here we investigated the combined effects of phospholipid polar headgroups and acyl chains on biophysical functions of membranes with solid-state ²H NMR spectroscopy. We compared the structural and dynamic properties of phosphatidylethanolamine and phosphatidylcholine with perdeuterated acyl chains in the solid-ordered (s_o) and liquid-disordered (l_d) phases. Our analysis of spectral lineshapes of 1,2-diperdeuteriopalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE-d₆₂) and 1,2-diperdeuteriopalmitoyl-sn-glycero-3-phosphocholine (DPPC-d₆₂) in the s_o (

SUBMITTER: Molugu TR 

PROVIDER: S-EPMC9674990 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature