Von Willebrand factor unfolding mediates platelet deposition in a model of high-shear thrombosis.

ABSTRACT: Thrombosis under high-shear conditions is mediated by the mechanosensitive blood glycoprotein von Willebrand factor (vWF). vWF unfolds in response to strong flow gradients and facilitates rapid recruitment of platelets in flowing blood. While the thrombogenic effect of vWF is well recognized, its conformational response in complex flows has largely been omitted from numerical models of thrombosis. We recently presented a continuum model for the unfolding of vWF, where we represented vWF transport and its flow-induced conformational change using convection-diffusion-reaction equations. Here, we incorporate the vWF component into our multi-constituent model of thrombosis, where the local concentration of stretched vWF amplifies the deposition rate of free-flowing platelets and reduces the sh

SUBMITTER: Zhussupbekov M 

PROVIDER: S-EPMC9675031 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature