Optimal transcriptional regulation of dynamic bacterial responses to sudden drug exposures.

ABSTRACT: Cellular responses to the presence of toxic compounds in their environment require prompt expression of the correct levels of the appropriate enzymes, which are typically regulated by transcription factors that control gene expression for the duration of the response. The characteristics of each response dictate the choice of regulatory parameters such as the affinity of the transcription factor to its binding sites and the strength of the promoters it regulates. Although much is known about the dynamics of cellular responses, we still lack a framework to understand how different regulatory strategies evolved in natural systems relate to the selective pressures acting in each particular case. Here, we analyze a dynamical model of a typical antibiotic response in bacteria, where a transcrip

SUBMITTER: Schultz D 

PROVIDER: S-EPMC9675034 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature