Longitudinal antibody titer, avidity, and neutralizing responses after SARS-CoV-2 infection.

ABSTRACT: While waning immunity and SARS-CoV-2 variant immune escape continue to result in high infection rates worldwide, associations between longitudinal quantitative, qualitative, and functional humoral immune responses after SARS-CoV-2 infection remain unclear. In this study, we found significant waning of antibody against Spike S1 (R = -0.32, p = 0.035) and N protein (R = -0.39, p = 0.008), while RBD antibody moderately decreased (R = -0.19, p = 0.203). Likewise, neutralizing antibody titer (ND₅₀) waned over time (R = -0.46, p = 0.001). In contrast, antibody avidity increased significantly over time for Spike S1 (R = 0.62, p = 6.0e-06), RBD (R = 0.54, p = 2.0e-04), and N (R = 0.33, p = 0.025) antibodies. Across all humoral responses, ND₅₀ strongly associated with Spike S1

SUBMITTER: Monroe JM 

PROVIDER: S-EPMC9675084 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature