Comprehensive analysis of TCGA data reveals correlation between DNA methylation and alternative splicing.

ABSTRACT: The effect of DNA methylation on the regulation of gene expression has been extensively discussed in the literature. However, the potential association between DNA methylation and alternative splicing is not understood well. In this study, we integrated multiple omics data types from The Cancer Genome Atlas (TCGA) and systematically examined the relationship between DNA methylation and alternative splicing. Using the methylation data and exon expression data, we identified many CpG sites significantly associated with exon expression in various types of cancers. We further observed that the direction and strength of significant CpG-exon correlation tended to be consistent across different cancer contexts, indicating that some CpG-exon correlation patterns reflect fundamental biological mech

SUBMITTER: Lin S 

PROVIDER: S-EPMC9675104 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature