Quantifying substantial carcinogenesis of genetic and environmental factors from measurement error in the number of stem cell divisions.

ABSTRACT:

Background

The relative contributions of genetic and environmental factors versus unavoidable stochastic risk factors to the variation in cancer risk among tissues have become a widely-discussed topic. Some claim that the stochastic effects of DNA replication are mainly responsible, others believe that cancer risk is heavily affected by environmental and hereditary factors. Some of these studies made evidence from the correlation analysis between the lifetime number of stem cell divisions within each tissue and tissue-specific lifetime cancer risk. However, they did not consider the measurement error in the estimated number of stem cell divisions, which is caused by the exposure to different levels of genetic and environmental factors. This will obscure the authentic contribution o

SUBMITTER: Liu X 

PROVIDER: S-EPMC9675110 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature