Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area.

ABSTRACT:

Background

The primary antibody (Ab) response to Plasmodium falciparum is a critical step in developing immunity to malaria. Information on the initial Ab responses of babies in malaria-endemic areas is incomplete, in part, because babies receive maternal IgG via transplacental-transfer and usually become infected before maternal IgG wanes. The study aimed to identify the primary IgM and IgG Ab responses to malarial antigens in Cameroonian babies.

Methods

Infants (n = 70) living in a high malaria transmission area were followed from birth throughout the first year of life (mean 341 ± 42 days, an average of 8.5 time points per infant). Malaria infection was assessed by microscopy and PCR, and IgM and IgG antibodies (Abs) were measured using a multiplex immunoassay to AMA1, EB

SUBMITTER: Tassi Yunga S 

PROVIDER: S-EPMC9675181 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature