Analysis of sputum microbial metagenome in COPD based on exacerbation frequency and lung function: a case control study.

ABSTRACT:

Background

The role of the sputum microbiome in chronic obstructive pulmonary disease (COPD) progression remains elusive. As the advent of the new culture-independent microbial sequencing technique makes it possible to disclose the complex microbiome community of the respiratory tract. The aim of this study was to use metagenomic next-generation sequencing (mNGS) to confirm whether there are differences in sputum microbiome of COPD between different exacerbation frequencies and lung function.

Methods

Thirty-nine COPD patients were divided into a frequent exacerbators (FE) group (n = 20) and a non-frequent exacerbators (NFE) (n = 19) group according to their exacerbation history, or a mild group (FEV₁/pre ≥ 50%, n = 20) and a severe group (FEV₁/pre < 50%

SUBMITTER: Li W 

PROVIDER: S-EPMC9675190 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature